1. Introduction: Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or. pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers.
Pyroglutamic acid has two specific forms known as enantiomers. These include D-pyroglutamic acid and L-pyroglutamic acid, with L-pyroglutamic acid being the biologically active enantiomer in humans. The primary biochemical use of L-pyroglutamic acid is believed to be increasing the activity of the neurotransmitter acetylcholine. It may also be used in the production of the neurotransmitters gamma-aminobutyric acid (GABA) and glycine. Acetylcholine acts on both the central nervous system and peripheral nervous system. It is also the only neurotransmitter that affects the motor portion of the somatic nervous system. Furthermore, acetylcholine is the primary neurotransmitter for the autonomic ganglia. Uses of L-Pyroglutamic Acid The most common uses of L-pyroglutamic acid deal with brain function due to its role. in supporting the healthy production of neurotransmitters. L-pyroglutamic acid is often used to support memory and learning in addition to managing anxiety. Memory recall support L-pyroglutamic acid may support both long-term and short-term memory recall. This effect relates to acetylcholine’s role in communication between brain cells. Learning support L-pyroglutamic acid may help to maintain communication between the two hemispheres of the brain. This benefit may help to support learning capability. Anxiety management Studies show that L-pyroglutamic acid may help to manage feelings of anxiety and stress. The results of this study also suggest that the specific mechanism of L-pyroglutamic acid is different from those of benzodiazepines.
2. Specification: White crystalline powder
3. Applications: (1) Medical intermediates, body supplements. (2) It has strong moisturizing function and strong penetration in skin. As a highly nutritious and easily absorbed additive, it can regulate the skin and act as a moisturizer.
Package: Packing volumes: 25kg Package: paper drum Transportation: by sea or by air or by land
Competitive Price: Place of Origin: China (mainland) Sales Method: Export, Manufacture, Wholesale, OEM/ODM, Service, Retail Payment Term: T/T
Chemical Name: L-Pyroglutamic acid
CAS No.: 98-79-3
1. Introduction: Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or. pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers.
Pyroglutamic acid has two specific forms known as enantiomers. These include D-pyroglutamic acid and L-pyroglutamic acid, with L-pyroglutamic acid being the biologically active enantiomer in humans. The primary biochemical use of L-pyroglutamic acid is believed to be increasing the activity of the neurotransmitter acetylcholine. It may also be used in the production of the neurotransmitters gamma-aminobutyric acid (GABA) and glycine. Acetylcholine acts on both the central nervous system and peripheral nervous system. It is also the only neurotransmitter that affects the motor portion of the somatic nervous system. Furthermore, acetylcholine is the primary neurotransmitter for the autonomic ganglia. Uses of L-Pyroglutamic Acid The most common uses of L-pyroglutamic acid deal with brain function due to its role. in supporting the healthy production of neurotransmitters. L-pyroglutamic acid is often used to support memory and learning in addition to managing anxiety. Memory recall support L-pyroglutamic acid may support both long-term and short-term memory recall. This effect relates to acetylcholine’s role in communication between brain cells. Learning support L-pyroglutamic acid may help to maintain communication between the two hemispheres of the brain. This benefit may help to support learning capability. Anxiety management Studies show that L-pyroglutamic acid may help to manage feelings of anxiety and stress. The results of this study also suggest that the specific mechanism of L-pyroglutamic acid is different from those of benzodiazepines.
2. Specification: White crystalline powder
3. Applications: (1) Medical intermediates, body supplements. (2) It has strong moisturizing function and strong penetration in skin. As a highly nutritious and easily absorbed additive, it can regulate the skin and act as a moisturizer.
Package: Packing volumes: 25kg Package: paper drum Transportation: by sea or by air or by land
Competitive Price: Place of Origin: China (mainland) Sales Method: Export, Manufacture, Wholesale, OEM/ODM, Service, Retail Payment Term: T/T
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